lacl3.7h20: an efficient catalyst for one-pot multi-component synthesis of 1,4-polyhydroquinoline derivatives through unsymmetrical hantzsch reaction.
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abstract
an efficient one pot multi component synthesis of 1, 4-polyhydroquinoline derivatives through unsymmetrical hantzsch reaction using lanthanum chloride heptahydrate (lacl3.7h2o) from an aromatic aldehyde, ethyl acetoacetate, dimedone and ammonium acetate as a nitrogen precursor in ethanol at room temperature is described. in the present work we report lanthanum chloride heptahydrate remarkably non-toxic in nature and ease of handling we explored the utility of lanthanum chloride as a catalyst for the synthesis of 1, 4-polyhydroquinoline derivatives. we newly report p-n, n-dimethylamino-cinnamaldehyde and m-chlorobenzaldehyde for the synthesis of 1, 4-polyhydroquinoline derivatives through unsymmetrical hantzsch reaction and was characterized by ir and 1hnmr spectroscopic methods.
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Journal title:
iranian chemical communicationجلد ۵، شماره Issue ۳. pp. ۲۶۱-۳۷۱، صفحات ۴-۶
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